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KMID : 0878220050170030103
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Journal of Sasang Constitutional Medicine
2005 Volume.17 No. 3 p.103 ~ p.112
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The Effects of Hyeongbangjihwang-tang and Sibimikwanjung-tang in Glycerol-Induced Renal Failure in Rats
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Lee Hyung-Sun
Kim Hyo-Soo
Kim Il-Hwna
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Abstract
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1.Objective :The present author have examined the comparative effects of Hyeongbangjihwang-tang and Sibimikwanjung-tang in glycerol-induced acute renal failure, a model for myoglobinuric acute renal failure.
2.Methods :Above two prescriptions were applied to rat ad libitum and serum level of creatinine, glucose and blood urea nitrogen(BUN) were measured. And serum level of Na+, K+, and Cl-, too. 50%(vol/vol) glycerol at a dose of 10 ml/kg of rat body weight intramuscularly and 1% concentration of prescriptions were applied to rats for 7 days ad libitum.
3.Results :Serum level of creatinine and K+ significantly increased by glycerol injection, and these showed pre-renal and renal cause of acute renal failure. Hyeongbangjihwang-tang administered group showed decreasing tendency on serum level of creatinine when compared with control groups, but not significant. Sibimikwanjung-tang administered group showed significant increase of serum level of BUN when compared with control groups.
4.Conclusions :Above two prescriptions showed no significant changes on glycerol induced acute renal failure, but Hyeongbangjihwang-tang and Sibimikwanjung-tang showed a little different manner of response.
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KEYWORD
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Hyeongbangjihwang-tang, Sibimikwanjung-tang, Glycerol-induced acute renal failure, Myoglobinuric acute renal failure
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